New 'morning after' pill meets opposition from abortion foes

MADRID, SPAIN - SEPTEMBER 27:  In this photo i...
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With global overpopulation among the most critical problems of the 21st century, news of a highly effective contraceptive becoming available in the U.S. would seem very good news indeed. But as health writer Rob Stein reports in the Washington Post, it may not happen:

A French drug company is seeking to offer American women something their European counterparts already have: a pill that works long after “the morning after.”

The drug, dubbed ella, would be sold as a contraceptive — one that could prevent pregnancy for as many as five days after unprotected sex. But the new drug is a close chemical relative of the abortion pill RU-486, raising the possibility that it could also induce abortion by making the womb inhospitable for an embryo.

Plan B (the last emergency contraceptive vetted by the FDA), which works for up to 72 hours after sex, was eventually approved for sale without a prescription, although a doctor’s order is required for girls younger than 17. The new drug promises to extend that period to at least 120 hours. Approved in Europe last year, ella is available as an emergency contraceptive in at least 22 countries.

“With ulipristal (ella), women will be enticed to buy a poorly tested abortion drug, unaware of its medical risks, under the guise that it’s a morning-after pill,” said Wendy Wright of Concerned Women for America, which led the battle against Plan B.

Plan B prevents a pregnancy by administering high doses of a hormone that mimics progesterone. It works primarily by inhibiting the ovaries from producing eggs. Critics argue it can also prevent a fertilized egg from implanting in the womb, which some consider equivalent to an abortion.

Ella works as a contraceptive by blocking progesterone’s activity, which delays the ovaries from producing an egg. RU-486, too, blocks the action of progesterone, which is also needed to prepare the womb to accept a fertilized egg and to nurture a developing embryo. That’s how RU-486 can prevent a fertilized egg from implanting and dislodge growing embryos. Ella’s chemical similarity raises the possibility that it might do the same thing, perhaps if taken at elevated doses. But no one knows for sure because the drug has never been tested that way. Opponents of the drug are convinced it will. “It kills embryos, just like the abortion pill,” said Donna Harrison, president of the American Association of Pro-Life Obstetricians and Gynecologists.

A federal panel will convene this week to consider endorsing the drug. Those favoring approval are worried that the ambiguous sentiments, and the power of abortion foes who seem poised to weigh in against it, will influence the outcome.

“FDA should be a ‘Just the facts ma’am’ organization,” said Susan F. Wood, an associate professor at the George Washington University School of Public Health and Health Services who resigned from the FDA to protest delays in making Plan B more accessible. “I’m hoping the FDA will take that position.”

There is an great unmet need out there for emergency contraception that is effective as this for so long,” said Erin Gainer, chief executive of HRA Pharma of Paris. Studies involving more than 4,500 women in the United States and Europe show that ella is safe, producing minor side effects including headaches, nausea and fatigue, she said.

The company has no plans to test ella as an abortion drug, but it did not appear to cause any problems for the handful of women who have become pregnant after taking the drug, she said.

“The people who are opposing this are not just opposed to abortion,” said Amy Allina, program director at the National Women’s Health Network. “They also opposed contraception and they are trying to confuse the issue.”

Back to the issue: the planet has a finite amount of space for human beings. When one human being (and often two human beings acting as one) seeks not to add an unwanted human being, would it not make sense to furnish all available safe, legal tools to assist in that humanitarian effort?

Stay tuned for the answer from the FDA.

New ‘morning-after’ pill, ella, raises debate over similarity to abortion drug.

Re eGadgets: will eReaders replace books?

In all the current talk about new eGadgets and their impact, the eBook has pretty much escaped condemnation — except for the dwindling population still committed to the printed page. And some of us hold-outs are beginning to waver.

Two old friends, Peter and Martha Klopfer, arrived from North Carolina yesterday with 60 or 70 books to get them through 10 days on the west coast. Peter, who is a Duke Professor Emeritus of biology,  and Martha, who is a thinker, runner, endurance rider and generally literate person, are prone to go off into the jungles of Madagascar or trekking in the Jordanian desert or climbing Machu Pichu. On these sorts of trips 30 or 40 books in their old-fashioned form are difficult to manage.

Enter the justifiable eReader.

There are by now enough eReaders to fill an old-fashioned 8 1/2 x 11″ piece of paper in 10-point Times Roman type. There’s the pioneering Kindle and the Kobo and the Nook and the Sony and of course the loudly heralded iPad, and there are probably a dozen others poised to debut.

But would you cuddle up with an eReader, asks Cynthia Ramnarace in an AARP Magazine blog?

Absorbing the written word isn’t what it once was. Whether you’re a new convert to e-reading or a die-hard fan of bound pages, you can’t ignore the evolution of reading. News reported by websites, e-mail and text messages is strangling printed newspapers. E-mail has replaced handwritten notes. And entire books can now be read on hand-held computers with a mere 6-inch screen.

The issue Ramnarace and others are debating is all about the reading experience. Can you be transported to another realm, as has always been true with paperbacks devoured on secluded beaches or under old trees in back yards — or under the covers with a flashlight for that matter, by a bunch of words on an eScreen? Maybe. But hard core print-book people think not.

“When books become computerized, you lose that contact with the maker,” says Cindy Bowden, director of the Robert C. Williams Paper Museum at Georgia Tech in Atlanta. “When you pick up a book, you notice the feel, the touch, the way the ink bleeds into the paper.”

If anybody thinks the paperback or its big brother hard cover will ultimately defeat the eBook onslaught, however, it is probably wise to think again. The copies you can buy in a bookstore that can’t also be bought in an eForm are getting fewer and farther between every day.

Not all books are available as e-books, but many are. Of the two industry leaders, Kindle boasts a library of 285,000 books, most for $9.99 each. The Sony Reader provides free access to 500,000 books in the public domain, including classics like Jane Austen and William Shakespeare; the Kama Sutra and the Bible; and contemporary works like Sue Grafton and Dennis Lahane, even “The DaVinci Code.” Another 100,000 are available for purchase from the Sony eBook Store.

Over time, e-readers could prove more economical than traditional books. For the price of buying 26 new hardcover books, one could also purchase the same number of e-books, plus the Kindle itself. And the devices allow readers to sample the first chapter of any book for free before purchase. Digitizing words could help elevate the medium, and in turn, boost a struggling publishing industry.

Peter and Martha are en route to the 40th annual Ride & Tie championship in Trout Lake, WA, where there is great beauty but not library and where they will celebrate their 55th anniversary in a manner somewhat more strenuous than most post-50th observances. After the race, there will be eReading.

Can You Love an Electronic Reader as Much as a Book? The Debate Is On – AARP Bulletin Today.

Is technology addiction messing with your brain?

my brains - let me show you them
Image by Liz Henry via Flickr

This is your life? Beginning at breakfast — or perhaps earlier, in the bathroom — one sizable screen with multiple streams of news, stock reports and data updates across the bottom; tweets in a box on the left; the iPhone nearby holding stacked up e-mails, IMs and calls that went into the mailbox? If so, you are not alone. As a matter of fact, it seems almost no one is alone, or disconnected from technological communications, any more. In the words of New York Times writer Matt Richtel, “This is your brain on computers.”

Scientists say juggling e-mail, phone calls and other incoming information can change how people think and behave. They say our ability to focus is being undermined by bursts of information.

These play to a primitive impulse to respond to immediate opportunities and threats. The stimulation provokes excitement — a dopamine squirt — that researchers say can be addictive. In its absence, people feel bored.

The resulting distractions can have deadly consequences, as when cellphone-wielding drivers and train engineers cause wrecks. And for millions of people … these urges can inflict nicks and cuts on creativity and deep thought, interrupting work and family life.

While many people say multitasking makes them more productive, research shows otherwise. Heavy multitaskers actually have more trouble focusing and shutting out irrelevant information, scientists say, and they experience more stress.

Richtel follows a family of four through their technology-addicted lives: they go on an oceanside vacation, but soon are all on their electronic devices; one day at the beach is mercifully unplugged. But on routine days, few moments are unplugged.

“And scientists are discovering,” Richtel reports, that even after the multitasking ends, fractured thinking and lack of focus persist. In other words, this is also your brain off computers.”

“The technology is rewiring our brains,” said Nora Volkow, director of the National Institute of Drug Abuse and one of the world’s leading brain scientists. She and other researchers compare the lure of digital stimulation less to that of drugs and alcohol than to food and sex, which are essential but counterproductive in excess.

Technology use can benefit the brain in some ways, researchers say. Imaging studies show the brains of Internet users become more efficient at finding information. And players of some video games develop better visual acuity.

More broadly, cellphones and computers have transformed life. They let people escape their cubicles and work anywhere. They shrink distances and handle countless mundane tasks, freeing up time for more exciting pursuits.

For better or worse, the consumption of media, as varied as e-mail and TV, has exploded. In 2008, people consumed three times as much information each day as they did in 1960. And they are constantly shifting their attention. Computer users at work change windows or check e-mail or other programs nearly 37 times an hour, new research shows.

The nonstop interactivity is one of the most significant shifts ever in the human environment, said Adam Gazzaley, a neuroscientist at the University of California, San Francisco.

“We are exposing our brains to an environment and asking them to do things we weren’t necessarily evolved to do,” he said. “We know already there are consequences.”

We just don’t fully understand what those consequences might be. This space worries. Couldn’t we get our adrenaline the old-fashioned way?

Your Brain on Computers – Attached to Technology and Paying a Price – NYTimes.com.

Aging brains can still follow the $$

day in the life: lunch money
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Balancing the checkbook isn’t as easy as it used to be? You can’t remember where you put the keys? OhmyGOODness, you say, I must be getting old.

The bad news is, age happens. The good news is, it does not necessarily bring a concurrent loss in cognitive ability. Get a new calculator, maybe one with a bigger keypad. Accept the fact that you’ve been misplacing the keys, occasionally, since you started driving.  And take heart in a new study from Duke University indicating that, all things considered, age is not a determining feature in the ability to make sound economic decisions.

Just because your mother has turned 85, you shouldn’t assume you’ll have to take over her financial matters. She may be just as good or better than you at making quick, sound, money-making decisions, according to researchers at Duke University.

“It’s not age, it’s cognition that makes the difference in decision-making,” said Scott Huettel, PhD, associate professor of psychology and neuroscience and director of the Duke Center for Neuroeconomic Studies. He recently led a laboratory study in which participants could gain or lose money based on their decisions.

“Once we accounted for cognitive abilities like memory and processing speed, age had nothing to do with predicting whether an individual would make the best economic decisions on the tasks we assigned,” Huettel said.

The study was published in the Psychology and Aging journal, published by the American Psychological Association.

Working with 54 older adults between 66 and 76 years old, and 58 younger adults between 18 and 35, the Duke researchers assigned a variety of economic tasks that required different types of risky decisions, so that participants could gain or lose real money.

On a bell curve of performance, there was overlap between the younger and older groups. Many of the older subjects (aged 66 to 76) made similar decisions to many of the younger subjects (aged 18 to 35). “The stereotype of all older adults becoming more risk-averse is simply wrong,” Huettel said.

Getting to the heart — and brain — of the issue, PositScience blogger Ted Baxa says “this finding will come as no surprise to many.  Legendary investor Warren Buffett, 79, continues to outperform fund managers half his age.  The message to take from this article is that age by itself, as the saying goes, is just a number.”

When you finish with the checkbook, in other words, you might want to get busy on your brain exercises.

Cognitive Ability, Not Age, Predicts Risky Decisions – DukeHealth.org.

Baby boomers & long-term care: innovation is the key

Baby boomers well into their final careers are increasingly discovering a new one: caregiver to elderly parents. And if current studies are to be believed, boomers themselves are more than likely to need long-term care. A new report out of Canada suggests that “baby boomers will have to develop non-traditional caregiver networks, or pay for long-term care facility care” in our neighbor to the north.

Today, up to 70% of the care provided to the elderly comes from an informal network of spouses, children and close family. But the baby-boom generation is unlike previous generations in that they have relatively few children, and stable couples are a rarity, according to researchers at the Université de Montréal. Baby boomers “risk finding themselves in difficult circumstances and might have to turn to the public system or pay their way,” says professor Jacques Légaré, who authored the study of aging boomers.

Friends, siblings or cousins could make up a new, non-traditional model of caregiving for seniors who can’t afford assisted living or skilled nursing care, Légaré suggests. The paper was presented this week at the 2010 Congress of the Humanities and Social Sciences at Concordia University in Montreal.

In the U.S., most surveys put the figure of “informal caregivers” — family members or friends — closer to 80%, and estimates of the number of boomers likely to need long-term care themselves go up with virtually every new study.

Choices in long-term care also are going up, though. The National Clearinghouse for Long-Term Care Information is a government-run (Department of Health and Human Services) site that offers information and resources for long-term care planning — along with some eye-opening information about costs and coverage.

Baby boomers can take heart in the fact that innovative models are being developed in many states, and possibilities are being pursued in both public and private sectors.  Non-traditional networks may be the new best thing for this looming fact of boomer futures.

Baby boomers may need to find new, innovative care networks, report finds – McKnight’s Long Term Care News.

Your arteries know your REAL age

1.11.09: CHD, here we come!
Image by Team Dalog via Flickr

Heart attacks, strokes and a long list of other artery-related afflictions top the list of health risks for the 50-and-over population — and a rising number of those even younger. So figuring how old you really are is an increasingly big deal. If your history includes cigarettes and fast food in abundance you might not want to know. But your arteries hold important information.

Wall Street Journal writer Ron Winslow reports on the intricate business of determining your vascular age — and why that’s an important determination to make.

Several tools are available that enable doctors and patients to calculate vascular age. These suggest there can be a substantial difference between how old you are and how old your blood vessels are. For instance, the vascular age of a 35-year-old man who smokes and has diabetes, high blood pressure and abnormal cholesterol could be as high as 76 years old—more than double his chronological age, according to a recent study. The arteries of a 30-year-old woman with similar risk factors could be equivalent to those of an average woman who is more than 80 years old.

Such a calculation “gives a sense that your risk-factor burden is making you age faster than you think you are,” says Donald Lloyd-Jones, a preventive cardiologist at Northwestern University, Chicago, who co-authored the recent study, which appeared in the journal Circulation last August. “The more you can make it concrete, the better you can impart information about risk.”

The good news, doctors say, is that by taking steps to reduce risk factors and the damage they inflict on arteries, it is possible to turn back the clock on vascular age.

Some of us — long-time smokers, members of a family with genetic problems that can’t be overcome — might not be able to access the good news. But many can, and for them, a few changes in lifestyle, or manageable medications, can make a lifetime of difference.

  • A 42-year-old man who smokes and has total cholesterol of 180, good cholesterol (HDL) of 45 and systolic blood pressure of 125, has a vascular age of a 54-year-old. If he quits smoking, his vascular age could drop to 42, the same as his chronological age.
  • A 52-year-old nonsmoking woman, who has total cholesterol of 220, HDL of 44 and systolic blood pressure of 135, has a vascular age of a 68-year-old. If the woman reduces her cholesterol below 200, her vascular age could drop to 59 years old.

If you’re feeling your age today, maybe your arteries are trying to tell you something.

Arteries Can Reveal Your Risk of Heart Disease – WSJ.com.

Abortion foes are winning, folks

WASHINGTON - JANUARY 22:  A pro-choice advocat...
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Will women in the U.S. soon be unable to have a safe, legal abortion? That scary possibility becomes more likely every day. Does anyone really understand the pre-Roe v Wade horrors which abortion foes want to see returned? Not really. That’s because huge numbers of women who could have told the horror stories died at the hands of back-alley abortionists, and those of us who did survive are dying off fast, unheard.

This space welcomes writer John Leland’s front page article in today’s New York Times to the voices crying in the wilderness — just in case someone other than Nancy Keenan might care to listen.

At least 11 states have passed laws this year regulating or restricting abortion, giving opponents of abortion what partisans on both sides of the issue say is an unusually high number of victories. In four additional states, bills have passed at least one house of the legislature.

In a flurry of activity last week, Gov. Haley Barbour of Mississippi signed a bill barring insurers from covering abortion in the new insurance exchanges called for under the federal health care overhaul, and the Oklahoma Legislature overrode a veto by Gov. Brad Henry of a bill requiring doctors who perform abortions to answer 38 questions about each procedure, including the women’s reasons for ending their pregnancies.

It was the third abortion measure this session on which the Legislature overrode a veto by Mr. Henry.

At least 13 other states have introduced or passed similar legislation this year. The new laws range from an Arizona ban on coverage of abortion in the state employees’ health plan to a ban in Nebraska on all abortions after 20 weeks, on the grounds that the fetus at that stage can feel pain.

Fetal pain is a subject of debate in the medical community, and the United States Supreme Court has recognized the government’s right to ban abortions only after a fetus becomes viable, which is more than a month later.

“Fetal pain” is just one ploy; its determination can easily go from 20 weeks backward to ban the morning-after pill. Other ploys? Forcing a pregnant woman to look at ultrasound pictures, prohibiting a physician from discussing fetal abnormalities with his/her patient, and “in Utah, after a pregnant 17-year-old paid a man $150 to beat her in an effort to induce a miscarriage, legislators passed a law that would allow a woman in such circumstances to be charged with homicide.”

Unwanted pregnancies happen. When they do, the man involved can simply walk away, as countless millions have done and will continue to do. Why, then, should so many men purporting to have such omnipotent wisdom be empowered to eliminate a woman’s right to choose what happens to her body?

It’s going to get worse. Unless people — and that includes males of the species who still have brains and some concern for the future of womankind — start paying attention, and standing up to the fundamentalists of all stripes, the U.S. Conference of Catholic Bishops and the religious factions who claim authority over all women, it’s going to get worse than many people in today’s society can even begin to imagine.

Opponents of Abortion Advance Cause at State Level – NYTimes.com.

Child predators & citizen cops: part two

Where are the limits to the rights of self-protection? Has the internet’s ability to make instant connections also created instant-cops who can go too far?

Earlier today I posted a story about a suspected predator in my local San Francisco park who turned out to be an innocent man — but only after his photo and suspicions of his being a predator had circulated widely on the internet and local TV, thanks to a campaign started by an anxious mom. She had spotted him near the playground, unaccompanied by a child.

Several readers have weighed in off-site to say I should have more sympathy for the mom, because she was only protecting her child and others. Maybe.

Years ago, when my own children were growing up in an urban area comparable in potential lurking dangers to San Francisco today, there was a man who appeared around elementary schools over a period of months, exposing himself to little girls. He became fairly famous among teachers, parents and children as “the man in the white car”, though he always managed to elude the police.

One afternoon when my then 7-year-old daughter was walking home alone (the school was about 3 blocks distant and the times were not quite so parentally protective) a white car pulled alongside her, stopped just ahead and the passenger-side door opened. But about a half block away was my 9-year-old son, lagging an appropriate distance behind.  He sped up, taking a pencil out of his pocket and calling his sister’s name, which was enough to cause the white car to scratch off — but not before they had written down his license number. Extraordinary children, of course, as they are mine, but to be truthful every kid in town had been so thoroughly trained in what to do it was practically a reflex reaction.

The man lived about a mile away. The police paid several calls on him. Because he had not been actually caught doing anything, and it had been over six months since the last episode, involving a child who couldn’t give any description, he was not accused of anything. But the police knew where he lived (as did I, since they drove my son by the house to reconfirm it was the car) and he knew they knew, and he knew his license number was in a file of some sort that could be easily found. That was the last episode involving the man in the white car and local schools.

Could he have gone on to frighten, and possibly molest, other children? Probably. Should we have painted a red “X” on his door, or taken his picture and put it up in the post office? I don’t think so. Plenty of phone calls flew back and forth, but there were no cellphone cameras or e-mails or internet sites at the time so the net was not cast quite as wide. And nobody called the TV station.

I am still pretty sure the man in the white car was a bad guy. We now know the man in the neighborhood park was not. In either case, there’s that business of being innocent until proven guilty. Trial by internet can mess with the system, which while imperfect is still the best we’ve got.

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